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Study finds genes that push weight gain in childhood, cause early puberty in girls

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New Delhi, July 1 (IANS) An international team of scientists has identified genes that can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood.

The team led by the University of Cambridge studied the DNA of around 800,000 women from Europe, North America, China, Japan, and Korea.

Their results, published in the journal Nature Genetics, showed more than 1,000 variants — small changes in DNA — that influence the age of the first menstrual period. Around 600 of these variants were observed for the first time, the team said.

Normally periods occur between ages 10 to 15, but this has been getting earlier and earlier in recent decades.

While the reasons are not fully understood, the study found that 45 per cent of the discovered genetic variants affected puberty indirectly, by increasing weight gain in early childhood.

“Many of the genes we’ve found influence early puberty by first accelerating weight gain in infants and young children. This can then lead to potentially serious health problems in later life, as having earlier puberty leads to higher rates of overweight and obesity in adulthood,” said Professor John Perry, at the varsity’s Medical Research Council (MRC) Epidemiology Unit.

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The scientists also analysed rare genetic variants that are carried by very few people, but which can have large effects on puberty. For example, they found that one in 3,800 women carry variants in the gene ZNF483, which caused these women to experience puberty on average, 1.3 years later.

Dr. Katherine Kentistou, lead study investigator said that the team “identified six genes which all profoundly affect the timing of puberty”.

Besides causing early onset of periods in girls, these genes often had “the same impact on the timing of puberty in boys”.

–IANS

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247 mn Indian 'entrepreneurial households' to drive $95 trillion in transaction value by 2043

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New Delhi, July 3 (IANS) India now has 247 million “entrepreneurial households” responsible for a whopping $8.8 trillion in transaction value for the fiscal year 2023, and expected to grow to $95.2 trillion by 2043 with an annual growth rate of 12.7 per cent, a report showed on Wednesday.

These “entrepreneurial households” will be key players in India’s next economic wave.

According to the report by Enmasse, Praxis Global Alliance, and Elevar Equity, the “entrepreneurial households” generate multiple income streams and use them along with borrowed funds to engage in high-value transactions involving important goods and services and business investments.

The report introduced a new term, ‘Core Transaction Value (CTV)’, which measures the total economic activity of these households, including all their earnings, borrowings, and spending.

“Given that we were taking a fresh approach to market sizing that felt almost impossible to begin — putting the customer segment first and not focusing on a sector or a product – we felt it is useful to provide additional visibility into our analysis and estimates, with triangulations from multiple sources,” said Madhur Singhal, Managing Partner and CEO, Praxis Global Alliance.

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“Brands targeting these households have seen high returns on investment, comparable to the top companies listed in the Nifty50 stock index,” the findings showed.

The report underscored the importance of these households in driving future economic growth and prosperity in India.

“For entrepreneurs and investors, this presents a unique opportunity to innovate and invest in this rapidly growing market, potentially reaping substantial returns,” it added.

The “entrepreneurial households” are characterised by their savvy allocation of cash towards consumption and investments, which is indicative of their economic vitality, more than traditional income measures.

–IANS

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India now has over 300 Family Offices from 45 in 2018 with smaller cities in focus: Report

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New Delhi, July 3 (IANS) Driven by robust economic growth in India, the country now has over 300 Family Offices as against 45 in 2018 who are catalysing the creation of jobs with an emphasis on responsible investing, a report showed on Wednesday.

Their number is set to rise exponentially, with promoters building impressive businesses in tier 2 and 3 cities, said the PwC India’s latest report.

The Indian economy is on a roll and contributing to its expansion are family businesses, both large conglomerates and small-to-medium-sized enterprises, spanning sectors such as manufacturing, retail, real estate, healthcare and finance and accounting for 60–70 per cent of the country’s GDP.

“Such Family Offices have catalysed the creation of jobs, entrepreneurship and a culture of self-reliance in the country, unlike those that have gone south owing to a lack of adaptability, succession planning, innovation, and effective governance,” said the report.

Family Offices have also evolved into holistic service providers, championing ESG and technology for sustainable wealth.

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“Over recent years, Family Offices have secured an integral spot in India’s financial ecosystem, offering specialised services tailored to the unique needs of high-net-worth individuals and business families,” said Falguni Shah, Partner and Leader, Entrepreneurial and Private Business, PwC India.

Amid these evolving trends, Family Offices also face several challenges. Building trust within family members and the family office is crucial but complex due to varying mindsets and interests.

“Family Offices in India are transforming wealth management by embracing technology, global diversification, and ESG principles. Their evolution from wealth preservation to impactful investing is crucial for sustainable growth and positive societal impact,” said Jayant Kumaar, Partner, Deals and Family Office Leader, PwC India.

–IANS

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Indian startups raised nearly $7 billion in first half of 2024

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New Delhi, July 3 (IANS) Indian startups have raised nearly $7 billion in funding during the first half (H1) of 2024, more than the $5.92 billion raised in H1 2023.

However, the figures are still far less than $20 billion in H1 2022, according to data compiled by TheKredible.

The $7 billion funding included 182 growth or late-stage deals worth $5.4 billion and 404 early-stage deals worth $1.54 billion. About 99 were undisclosed deals, reports Entrackr.

During H1, Indian startups produced a couple of unicorns — Perfios and Krutrim SI Designs. Last year, only two startups managed to cross the unicorn valuation while 2022 and 2021 witnessed the emergence of 26 and 44 unicorns, respectively.

When it comes to month-on-month trends, June witnessed nearly $2 billion in funding which is more than double the average of $1 billion monthly funding until May this year, the report mentioned.

Late-stage companies such as Zepto, Flipkart, PharmEasy and Lenskart topped with $665 million, $350 million, $216 million, and $200 million funding, respectively.

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Moreover, H1 2024 saw 55 mergers and acquisitions, which is lower when compared to 2023. The year 2021 witnessed over 250 mergers and acquisitions which dropped to 204 in 2022 and further reduced to 145 in 2023.

Segment-wise, e-commerce topped the list with 124 startups raising more than $1.87 billion. Fintech, healthtech, SaaS and EV startups were next on the list. Amount-wise, EV startups secured more funding than SaaS and healthtech. Agritech, foodtech, edtech and proptech saw a decline in funding during H1 2024.

–IANS

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After layoffs, Unacademy CEO denies rumours of merger, acquisition

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New Delhi, July 3 (IANS) After reported layoffs of around 250 employees in the latest job cuts, edtech firm Unacademy Co-founder and CEO Gaurav Munjal on Wednesday denied the reports of a possible merger or an outright acquisition, saying “ignore the rumours”.

“There is a lot being said about Unacademy currently,” Munjal wrote in a post on X.

He further said that the edtech firm have its best year in terms of growth and profitability and many years to run the company.

“To set the record straight, Unacademy will have its best year in terms of growth and profitability. We also have many years of runway. We are building Unacademy for the long run,” the CEO said.

As per reports, Unacademy has approached coaching institute Allen, edtech firm Physics Wallah, education services company K12 Techno and other large education coaching companies.

According to TechCrunch, citing sources, the edtech firm will be letting go of 100 employees from marketing, business and product, and about 150 in sales.

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The layoffs bring Unacademy’s total job cuts to around 2,000 since the second half of 2022.

Last month, Munjal, in a post, commented on edtech firm Byju’s fall.

He said that Byju Raveendran, Founder and Group CEO of Byju’s, faced setbacks as he put himself on a pedestal and stopped listening to anyone.

“Byju failed because he didn’t listen to anyone. He put himself on a pedestal and stopped listening. Don’t do that. Never do that. Don’t listen to everyone but have people who can give you blunt feedback,” Munjal said.

“You might not always like the feedback, but take the feedback and act on it,” he added.

–IANS

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Pune Zika cases rise to 8: Centre issues advisory to states to step up vigil

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New Delhi, July 3 (IANS) Amid the rise in Zika virus cases in Pune, the Centre, on Wednesday, issued an advisory to all states asking them to step up vigil.

Zika virus disease (ZVD) is a mosquito-borne disease transmitted by Aedes mosquitoes. While it is usually mild to moderate disease in adults and requires no specific treatment, in pregnant women, it may cause microcephaly — a condition in which the head is significantly smaller due to abnormal brain development — in the foetus.

Maharashtra has reported eight cases of Zika virus till July 2. Of these, six are from Pune, one each from Kolhapur and Sangamner, and 2 are pregnant women.

“In view of some reported cases of Zika virus from Maharashtra, Dr Atul Goel, Director General of Health Services (DGHS), has issued an advisory to states highlighting the need for maintaining a state of constant vigil over the Zika virus situation in the country,” the Health Ministry said.

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The ministry urged states “to instruct the health facilities in the affected areas or those catering cases from affected areas to screen the pregnant women for Zika virus infection.”

The health workers must also “monitor the growth of the foetus” of Zika-positive women and “act as per Central government guidelines,” the ministry said.

It also asked health facilities and hospitals to identify a nodal officer to monitor and act to keep the premises free of Aedes mosquitoes.

Besides, the advisory called on states to “strengthen entomological surveillance and intensify vector control activities in residential areas, workplaces, schools, construction sites, institutions, and health facilities.”

Currently, Zika testing facilities are available at the National Institute of Virology (NIV), Pune; the National Centre for Disease Control (NCDC), Delhi; and a few selected virus research and diagnostic laboratories of the Indian Council of Medical Research (ICMR).

The ministry will continue to monitor the situation closely, the advisory noted.

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–IANS

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