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Scientists find potential treatment target for leading cause of blindness

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New Delhi, May 2 (IANS) US scientists have found answers to why treatment for neovascular age-related macular degeneration (AMD) — a leading cause of blindness — does not benefit all; and also developed a potential antibody treatment.

AMD is a condition characterised by abnormal blood vessel growth in the back of the eye.

Older age, diabetes, obesity, and many other chronic metabolic diseases lead to excessive vascular growth and damage to the macula — the part of the eye that translates light into image signals.

The first line of defence is usually the Anti-VEGF therapy, which blocks vascular endothelial growth factor and keeps excessive blood vessel growth at bay. However, it only works well for around a third of patients, said the team from the Medical College of Georgia (MCG).

“Fibroblast cells” are the reason, they found.

“Collagen and many other proteins produced by these fibroblast cells accumulate outside of the vascular cells and eventually lead to fibrosis or scarring in the eye. This keeps the excess vasculature from being suppressed by anti-VEGF treatments,” revealed the study, published in the journal Science Translational Medicine.

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“We show, for the first time in this study, that many fibroblast cells are actually produced by these excessive endothelial cells,” said Yuqing Huo, the Director of the Vascular Inflammation Programme at MCG’s Vascular Biology Center.

To prevent this from happening, the team targeted the adenosine receptor 2A (Adora2a) — a G-protein-coupled adenosine receptor found in high levels in the brain, immune cells, and blood vessels.

Although crucial in modulating inflammation, myocardial oxygen consumption, and coronary blood flow, in excess, adenosine can lead to excessive blood vessel growth.

Using genetically engineered mice that develop fibrosis in the backs of their eyes, the researchers delivered an Adora2a agonist (KW6002), which binds to the receptor and blocks its function. The mice demonstrated decreased fibrosis in the eye, the team said.

“An antibody could really block both excessive blood vessel growth, the early stage of AMD, and fibrosis, the late stage of AMD. Our findings indicate that blocking Adora2a can certainly target multiple stages of this disease, which might be much more efficient than current treatments,” Huo said.

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–IANS

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Property, land registration comes to a halt in Telangana

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Hyderabad, July 11 (IANS) Property and land registration came to a halt in Telangana on Thursday after Aadhaar online services across the country were suspended due to some technical problems in the UIDAI network.

Suspension of Aadhaar online services interrupted Aadhaar-based OTP services and registrations. This also affected the property and land registration services in Telangana.

Since the Aadhaar biometric is mandatory for registrations, the registration services came to a grinding halt. “Inconvenience caused to registering public is highly regretted. The issues are due to fluctuations at UIDAI, Aadhar based services,” read a message on the website of the Registration and Stamps Department.”

According to the Chief Minister’s Office, the registration services will resume by Friday.

Meanwhile, Chief Minister A. Revanth Reddy on Thursday held a review meeting with revenue-generating departments at the state Secretariat. The meeting was attended by Deputy Chief Minister and Finance Minister Mallu Bhatti Vikramarka, Revenue Minister P. Srinivas Reddy, Excise Minister Jupally Krishna Rao, Chief Secretary Santhi Kumari and other officials. The meeting reviewed the revenue generation from various departments like Finance, Commercial Taxes, Prohibition & Excise, Registration and Mines & Geology.

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–IANS

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Indians travelling to Qatar will soon be able to make UPI payments

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New Delhi, July 11 (IANS) NPCI International Payments Ltd (NIPL), the international arm of the National Payments Corporation of India (NPCI), on Thursday signed an agreement with QNB, the largest financial institution in the Middle East and Africa, headquartered in Qatar, to launch QR code-based Unified Payments Interface (UPI) payments across the Gulf nation.

This will enable UPI payment acceptance in Qatar through the QNB merchant network, benefiting Indian travellers visiting and transiting through the country.

“We believe that enabling UPI acceptance in Qatar will offer substantial benefits to the large number of Indians visiting the country, simplifying their transactions, and ensuring a hassle-free travel experience abroad,” Anubhav Sharma, Deputy Chief – Partnerships and Business Development, NPCI International, said in a statement.

This partnership will provide Indian tourists the option to use their preferred payment method across retail stores, tourist attractions, leisure sites, duty-free shops, and hotels.

“With this new digital payment solution acceptance, we are revolutionising the way transactions are conducted, enhancing the travel experience like never before,” said Adel Ali Al-Malki, Senior Executive VP, QNB Group Retail Banking.

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By adopting UPI payments, merchants in Qatar will also be able to offer a faster and more convenient payment and checkout process.

–IANS

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India IT spending expected to see close to 19 pc growth this year: Report

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New Delhi, July 11 (IANS) IT spending in India is expected to witness close to 19 per cent growth in 2024, whereas, globally, it is expected to see about 8 per cent growth, a new report said on Thursday.

According to Grant Thornton Bharat, the second quarter (Q2) of the calendar year 2024 (April-June) saw an increase in deal volumes by 9 per cent, from 69 to 75.

“The Indian technology industry is showing promising signs of revival and stabilisation. Generative AI is driving new opportunities for growth and innovation, with CIOs focusing on enhancing customer experience and operational efficiency,” said Raja Lahiri, Partner and Technology Industry Leader at Grant Thornton Bharat.

In Q2, PE (private equity) volumes have increased since Q3 2023, reaching the highest in two years.

Technology startups dominated PE activity with 60 per cent of volumes and 57 per cent of values, whereas, the enterprise software/SaaS segment accounted for 30 per cent of volumes, according to the report. B2B (business-to-business) startups led PE deal activity accounted for 74 per cent of volumes and 51 per cent of values in Q2.

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Avail Technologies, a B2B startup, secured $70 million in funding across two rounds to enhance product development and expand globally. Logistics services platform Perfios and Ola’s Krutrim AI achieved unicorn status in 2024. The enterprise software/SaaS segment recorded 20 transactions worth $79 million.

–IANS

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Indian companies keen to explore investment opportunities in Austria: Industry

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Vienna, July 11 (IANS) Indian companies are keen to explore investment opportunities in Austria across areas such as Research and Development, artificial intelligence (AI) and software in sustainability areas for addressing the European market, industry experts as Prime Minister Narendra Modi concluded his historic visit to the country.

Speaking at the India-Austria Business Forum in Vienna, organised by the Confederation of Indian Industry (CII) with Austrian Federal Economic Chamber and Federation of Austrian Industries in conjunction with Prime Minister Narendra Modi’s visit to Austria, Martin Kocher, Minister of Labour and Economy, Austria stressed that we value the Indian startup ecosystem as one of the most vibrant in the world.

He added that there are cooperation opportunities in renewable energy, smart cities, audio-visual and films, tourism and other sectors.

Sanjiv Puri, President, CII, said we must encourage two-way cooperation in sustainable agriculture, water treatment and food processing.

“In critical areas in sustainability cooperation of circularity, adaptation to weather disruptions and biodiversity, Austrian technology partnerships can help India in these areas through AI, advanced sensors and other new tech instruments,” said Puri.

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Talking about India-Austria trade relations, R. K. Singh, Secretary, Department for Promotion of Investments and Internal Trade, Ministry of Commerce and Industry said that the two-way trade between India and Austria is worth about $2 billion which is relatively well balanced.

“Most MNCs who have invested in India, including many European ones who have stayed the course have reaped rich dividends in terms of outshining their parents, both in terms of topline and bottom-line expansion, profitability as well as enterprise value,” said Singh.

–IANS

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TCS hires 5,452 employees in Q1, reverses drop in headcounts

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Bengaluru, July 11 (IANS) IT services major Tata Consultancy Services (TCS) hired 5,452 employees in the first quarter of the ongoing fiscal (FY25), reversing three-quarters of the drop in headcount.

The company’s headcount had fallen for the first time in 19 years during FY24.

The company now employs 6,06,998 people. The attrition rate came further down to 12.1 per cent in the Q1 FY25, said the company.

After presenting the quarterly result (Q1 FY25) where it reported a 9 per cent year-on-year increase in net profit at Rs 12,040 crore, Chief Human Resources Officer Milind Lakkad said he is “delighted to announce the successful completion of our annual increment process”.

“Our continued focus on employee engagement and development led to industry-leading retention and strong business performance, with the net headcount addition being a matter of immense satisfaction,” Lakkad added.

For Q1, TCS clocked revenue of Rs 62,613 crore, up 5.4 per cent from the same quarter last year.

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“We are continuing to expand our client relationships, create new capabilities in emerging technologies and invest in innovation, including a new AI-focused TCS PacePort in France, IoT lab in the US and expanding our delivery centres in Latin America, Canada and Europe,” said K Krithivasan, Chief Executive Officer and Managing Director.

–IANS

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