Health/medicine
Nipah monoclonal antibody to undergo human trials in India, Bangladesh in 2025
New Delhi, July 4 (IANS) A novel monoclonal antibody against the Nipah virus is set to undergo human clinical trials in India, and Bangladesh — two countries that suffer Nipah outbreaks almost every year — in 2025, according to a report on Thursday.
Nipah virus, a zoonotic disease of the Paramyxovirus family, kills up to 75 per cent of the people it infects. The lethal disease also has a high transmission rate. To date, there are no approved treatments or vaccines against it.
The trial aims to assess the safety and tolerability of Nipah monoclonal antibody (mAb) MBP1F5 — developed by the US-based Mapp Biopharmaceutical — a protein that mimics natural antibodies by binding to the virus and preventing infection.
The company has received $43.5 million in funding from the Coalition for Epidemic Preparedness Innovations (CEPI) and is intended to commence human trials in 2025, pending regulatory approval.
The trial will assess MBP1F5 in healthy adults at multiple clinical trial sites in India and Bangladesh.
The funding will also support preclinical studies seeking to expand the use of the mAb from pre-exposure prophylaxis (before someone is exposed to a virus) to post-exposure prophylaxis, that is, for people shortly after infection with the virus.
“A monoclonal antibody capable of offering immediate protection for caregivers and others at risk of infection would be an important addition to our armamentarium against the Nipah virus,” said Richard Hatchett, CEO of the Coalition for Epidemic Preparedness Innovations (CEPI).
The new Nipah mAb can bind to the Nipah virus F protein — preventing the virus from entering a host cell and causing infection in people. This mechanism can offer protection against both known strains of Nipah virus (Bangladesh and Malaysia) and its closely related viral cousin, Hendra virus, for at least six months — enough time for vaccine immunity to build, according to the company researchers.
According to Brent Yamamoto, from Mapp, in preclinical models, MBP1F5 has shown incredible potential for preventing and treating Nipah.
–IANS
rvt/svn
Health/medicine
Not all animal diseases are zoonotic: Animal Husbandry department
New Delhi, July 7 (IANS) Zoonoses are infectious diseases that can transfer between animals and humans, such as rabies, anthrax, influenza (H1N1 and H5N1), Nipah, Covid-19, brucellosis, and tuberculosis; however, not all diseases are ‘zoonotic’, said the Department of Animal Husbandry and Dairying (DAHD) on Sunday.
The department has organised an interactive session chaired by the Secretary of Animal Husbandry and Dairying (AHD) to observe the World Zoonoses Day
According to the Animal Husbandry Department, understanding which diseases are zoonotic is crucial for effective public health strategies and preventing unnecessary fear and stigmatisation of animals.
“Raising awareness aids in early detection, prevention, and control, ultimately protecting public health. Educating the public about the distinction between zoonotic and non-zoonotic diseases helps reduce unwarranted fear and promotes a more informed approach to animal health and safety,” said DAHD.
To mitigate the risk of zoonotic diseases, DAHD has launched a nationwide campaign for Brucella vaccination of bovine calves under the National Animal Disease Control Programme and undertaken rabies vaccination under Assistance to States for Control of Animal Diseases.
The department said that it is also implementing a comprehensive nationwide surveillance plan for economically important animal diseases.
Additionally, under the One Health approach, the National Joint Outbreak Response Team has been established, comprising experts from the Ministry of Health and Family Welfare, ICMR, DAHD, ICAR, and the Ministry of Environment, Forest and Climate Change.
India has the largest livestock population, with 536 million livestock and 851 million poultry, which accounts for nearly 11 per cent and 18 per cent of the global livestock and poultry population, respectively.
India is the world’s largest producer of milk and the second-largest producer of eggs.
World Zoonoses Day is celebrated in honour of Louis Pasteur, who administered the first successful rabies vaccine, a zoonotic disease, on July 6, 1885.
–IANS
shs/khz
Health/medicine
Anand Mahindra shares video of new tech detecting veins using infrared light
New Delhi, July 7 (IANS) Mahindra Group Chairman Anand Mahindra has shared a video on the social media platform X, showing a new technology detecting veins using infrared light.
“Using infrared light to locate veins. Saving the pain from repeated attempts to find a vein when drawing blood,” he wrote.
Praising the technology, the Mahindra Group Chairman said that it’s often the smallest, least glamorous inventions which “significantly improve our medical experience and hence, the quality of our lives”.
Since being shared, the video has been viewed over 680K times. A lot of users also shared their thoughts in the comment section.
“This is brilliant and could prevent a lot of phobias. From personal experience, the practicality of this would have saved a number of traumas. Helps the professional and the patient,” a user wrote.
“We need this Tech at local blood test centres; last year, my yearly check-up nurse did four punctures in my hands,” another user said.
One more user mentioned, “This will be really helpful. My mom faces this challenge when we do blood tests for her and it requires an experienced person to identify the vein. This technology can enable a lot of people in the medical industry.”
–IANS
shs/uk
Health/medicine
S. Korea expected to announce steps against defiant trainee doctors this week
Seoul, July 7 (IANS) The South Korean government is expected to announce measures to deal with trainee doctors who refuse to return to hospitals in protest of medical reform as early as this week, officials said on Sunday.
The government is set to announce its measures on the junior doctors, who have left their worksites since late February, as early as Monday, according to government officials.
Health Minister Cho Kyoo-hong earlier pledged to introduce such measures in early July, as hospitals need to prepare for the recruitment of new junior doctors who will begin training in September, reports Yonhap News Agency.
The government has currently decided to halt the suspension of medical licences of those who return to work.
As of Thursday, 1,104 junior doctors, or 8 per cent of 13,756 trainee doctors, were on duty at the country’s 211 training hospitals, according to government data.
Trainee doctors have been on strike for nearly five months in protest against a hike in medical student admissions, the first such increase in 27 years, which was finalised in May.
The government initially instructed hospitals to not accept trainee doctors’ resignations to prevent them from seeking other jobs but reversed this order in late June to normalise operations.
As the protracted walkout by trainee doctors has shown little signs of ending, medical professors, who also serve as senior doctors at general hospitals, began staging walkouts and other forms of protest.
–IANS
shs/kvd
Health/medicine
Rising dengue cases cause of worry at the onset of monsoon in West Bengal
Kolkata, July 6 (IANS) Early trend is hinting at the possibility of the spread of dengue during the monsoon season in West Bengal with the total number of affected people having already crossed the 2,000 mark at the end of the first week of July.
Sources in the Health Department said the number of affected people till July 4 has already touched 2,095, adding that the figures could be more since not all the cases have been reported, with Malda and Murshidabad districts leading the tally.
The number of cases in Durgapur, the industrial township in West Burdwan district, is also substantially high.
The sources added that Health Department officials are in constant touch with the different civic authorities to ensure that the situation does not get out of control.
The dengue menace took an alarming shape in 2023 when the state reported over 76,000 cases till November last year, which was around 10,000 more than the 2022 figures.
With the full-fledged monsoon yet to arrive in the state, the medical fraternity is not ruling out the probability of Bengal reporting a large number of dengue cases this year as well.
The medical fraternity is also emphasising that the Health Department should report all dengue cases to the National Centre for Vector Borne Diseases Control (NCVBDC).
Last year, West Bengal was the only state that did not share any data on this count with the central monitoring agency.
–IANS
src/arm
Health/medicine
Class X student drops dead on school corridor due to heart failure in Rajasthan
Jaipur, July 6 (IANS) In a tragic incident, a tenth-standard student died due to heart failure at a school in Bandikui in Rajasthan’s Dausa district on Saturday.
The deceased identified as Yatendra (16) reached the school at 7.30 a.m. on Saturday but collapsed on the corridor just before entering the classroom.
The school administration immediately rushed Yatendra to a nearby hospital where he died during treatment.
Circle Inspector Premchand said, “Yatendra, the son of Bhupendra Upadhyay studying in a private school on Panditpura Road, suddenly fell unconscious on Saturday morning. The school staff took him to the Bandikui Government Hospital the doctors declared him dead after 10 minutes of treatment. According to the doctors, Yatendra died due to heart failure.”
As per reports, Yatendra had a hole in his heart since childhood for which he was undergoing treatment.
“The deceased’s family refused to conduct a post-mortem. Going by the doctor’s statement and Yatendra’s medical history, the police have not filed any case in the matter. The family has left for their ancestral village at Narwas in Alwar to perform the last rites.”
Bhupendra Upadhyay, the deceased’s father, said: “Yatendra turned 16 only on Friday. He even distributed toffees among his schoolmates and cut a cake at home. He also got photographs taken with the family members. But yesterday’s happiness has turned into sorrow today.”
–IANS
arc/arm
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