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New method may detect early ovarian cancer from urine test

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New York, Feb 10 (IANS) Ovarian cancer is hard to diagnose in its early stages because it has vague symptoms, such as constipation, bloating, and back pain. Moreover, there are no routine screens for ovarian cancer like there are with other cancers, such as breast or colon cancer.

New research by Joseph Reiner and colleagues at Virginia Commonwealth University in the US shows promise for a urine-based test for ovarian cancer.

Previous research showed that there are thousands of small molecules, called peptides, in the urine of people with ovarian cancer.

While it is possible to detect those molecules using certain well-established techniques, those techniques aren’t straightforward or cost effective. Reiner sought a new approach to more easily detect those peptides.

He turned to nanopore sensing, which has the potential to simultaneously detect multiple peptides.

The basic idea of nanopore sensing involves passing molecules through a tiny pore, or nanopore, and measuring the changes in electrical current or other properties as the molecules move through.

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To harness the nanopore technology to detect various peptides, Reiner used gold nanoparticles that can partially block the pore.

Peptides, like those in the urine of people with ovarian cancer, will then “stick to the gold particle and basically dance around and show us a unique current signature,” Reiner explained.

The method is capable of simultaneously identifying multiple peptides, and in their study they identified and analyzed 13 peptides, including those derived from LRG-1, a biomarker found in the urine of ovarian cancer patients.

Of those 13 peptides, Reiner said, “we now know what those signatures look like, and how they might be able to be used for this detection scheme. It’s like a fingerprint that basically tells us what the peptide is.”

“Clinical data shows a 50-75 per cent improvement in 5-year survival when cancers are detected at their earliest stages. This is true across numerous cancer types,” Reiner noted.

Their ultimate goal is to develop a test that, combined with other information like CA-125 blood tests, transvaginal ultrasound, and family history, could improve early-stage ovarian cancer detection accuracy in the future.

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Ovarian cancer has only a 35 per cent overall survival rate. A more straightforward screening process could improve early diagnosis and lead to a better survival rate.

–IANS

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NSE warns investors against persons promising assured returns in stock market

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New Delhi, July 3 (IANS) The National Stock Exchange (NSE) issued an advisory on Wednesday cautioning investors of certain individuals and Telegram channels offering securities market tips and assured returns on stock market investments.

The exchange said in a statement that investors are cautioned and advised not to subscribe to any such scheme/product offered by any person/entity offering indicative/assured/guaranteed returns in the stock market, as the same is prohibited by law.

The NSE said that a person named “Ajay Kumar Sharma” operating through the mobile number “7878337029” and Telegram channel “Bharat Trading Yatra” and an individual named “Ranveer Singh” operating through the mobile number “9076273946” and Telegram channel “Bullish Stocks” — are “providing assured returns on investment in stock market and offering to handle trading account of investor by asking investors to share their Login ID/password”.

“It may also be noted that the said person/entity are not registered either as a member or authorised person of any registered member of the NSE,” said the exchange.

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The stock exchange also advised investors not to share their trading credentials, such as user ID/password, with anyone.

In addition, the NSE mentioned that participation in such prohibited schemes is at investors’ own risk, cost and consequences as “such schemes are neither approved nor endorsed by the exchange”.

–IANS

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Low rainfall & high CO2 can replace India's biodiversity hotspots: Study

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New Delhi, July 3 (IANS) Even as greenhouse gasses are increasing unprecedentedly, it can decrease rainfall in the equatorial region as well as affect India’s biodiversity hotspots, according to a new study on Wednesday.

The study showed that it will potentially replace India’s biodiversity hotspots consisting of evergreen forests in the Western Ghats, northeast India, and the Andamans with deciduous forests.

For the study researchers from Birbal Sahni Institute of Palaeosciences (BSIP), an autonomous institute of the Department of Science and Technology, used fossil pollen and carbon isotope data from the Eocene Thermal Maximum 2 (ETM-2), also known as H-1 or Elmo.

It is a period of global warming that occurred around 54 million years ago.

In addition to global warming, during this period the Indian plate also lingered near the equator during its journey from the southern to northern hemisphere.

“This makes the Indian plate a perfect natural laboratory that offers a peculiar opportunity to understand the vegetation-climate relationship near the equator during the ETM-2,” the researchers said.

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Based on the availability of fossils from ETM2, the team selected the Panandhro Lignite Mine of Kutch in Gujarat and collected fossil pollen from there.

Their findings, published in the journal Geoscience Frontiers, found that when atmospheric carbon dioxide (CO2) concentration was more than 1000 parts per million by volume (ppmv) near the palaeo-equator, the rainfall decreased significantly. It led to the expansion of deciduous forests.

The study also raises important questions about the survival of equatorial/ tropical rainforests and biodiversity hotspots under increased carbon emissions. It can also help understand the relationship between CO2 and hydrological cycle and aid in the future conservation of biodiversity hotspots.

–IANS

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JNCASR team propose a new measure of flexibility for crystals

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New Delhi, July 3 (IANS) Researchers at the Jawaharlal Nehru Centre for Advanced Scientific Research, (JNCASR), an autonomous institution under the Department of Science & Technology, have introduced a novel quantitative measure of mechanical flexibility for crystals.

The measure can be used to screen materials databases to identify next-generation flexible materials, said the team.

They carried out an in-depth analysis of the mechanisms underlying the flexibility of crystals of Metal-organic frameworks (MOFs) — a large class of crystalline materials that possess the remarkable ability to absorb gasses, such as carbon dioxide, and store them as well as act as filters for crude oil purification.

The team attributed the flexibility to large structural rearrangements associated with soft and hard vibrations within a crystal that strongly couple to strain fields.

The analysis opens doors to innovative materials with diverse applications in various industries, said the researchers.

MOFs derive their ability from the presence of nanopores, enhancing their surface areas that, in turn, make them adept at absorbing and storing gases. However, limited stability and mechanical weakness have hindered their broader applications, which was addressed by the new measure.

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The new findings, published in the journal Physical Review B, present groundbreaking insights into the origin of mechanical flexibility. Flexibility in crystals has, historically, been assessed in terms of a parameter called elastic modulus — a measure of a material’s resistance to strain-induced deformation, but, on the contrary, the study “proposes a unique theoretical measure based on the fractional release of elastic stress or strain energy through internal structural rearrangements under symmetry constraints”.

Using theoretical calculations, the team examined the flexibility of four different systems with varying elastic stiffness and chemistries. The results showed that “flexibility arises from large structural rearrangements associated with soft and hard vibrations within a crystal that strongly couples to strain fields”.

The newfound measure of flexibility is also poised to revolutionise materials science, especially in the context of MOFs. “This theoretical framework enables the screening of thousands of materials in databases, providing a cost-effective and efficient way to identify potential candidates for experimental testing. The design of ultra-flexible crystals becomes more achievable, offering a practical solution to the challenges posed by traditional experimental methods,” said Professor Umesh V. Waghmare from the Theoretical Sciences Unit at JNCASR.

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The potential applications of this research extend beyond the realm of physics, opening doors to innovative materials with diverse applications in various industries, the team said.

–IANS

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247 mn Indian 'entrepreneurial households' to drive $95 trillion in transaction value by 2043

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New Delhi, July 3 (IANS) India now has 247 million “entrepreneurial households” responsible for a whopping $8.8 trillion in transaction value for the fiscal year 2023, and expected to grow to $95.2 trillion by 2043 with an annual growth rate of 12.7 per cent, a report showed on Wednesday.

These “entrepreneurial households” will be key players in India’s next economic wave.

According to the report by Enmasse, Praxis Global Alliance, and Elevar Equity, the “entrepreneurial households” generate multiple income streams and use them along with borrowed funds to engage in high-value transactions involving important goods and services and business investments.

The report introduced a new term, ‘Core Transaction Value (CTV)’, which measures the total economic activity of these households, including all their earnings, borrowings, and spending.

“Given that we were taking a fresh approach to market sizing that felt almost impossible to begin — putting the customer segment first and not focusing on a sector or a product – we felt it is useful to provide additional visibility into our analysis and estimates, with triangulations from multiple sources,” said Madhur Singhal, Managing Partner and CEO, Praxis Global Alliance.

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“Brands targeting these households have seen high returns on investment, comparable to the top companies listed in the Nifty50 stock index,” the findings showed.

The report underscored the importance of these households in driving future economic growth and prosperity in India.

“For entrepreneurs and investors, this presents a unique opportunity to innovate and invest in this rapidly growing market, potentially reaping substantial returns,” it added.

The “entrepreneurial households” are characterised by their savvy allocation of cash towards consumption and investments, which is indicative of their economic vitality, more than traditional income measures.

–IANS

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India now has over 300 Family Offices from 45 in 2018 with smaller cities in focus: Report

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New Delhi, July 3 (IANS) Driven by robust economic growth in India, the country now has over 300 Family Offices as against 45 in 2018 who are catalysing the creation of jobs with an emphasis on responsible investing, a report showed on Wednesday.

Their number is set to rise exponentially, with promoters building impressive businesses in tier 2 and 3 cities, said the PwC India’s latest report.

The Indian economy is on a roll and contributing to its expansion are family businesses, both large conglomerates and small-to-medium-sized enterprises, spanning sectors such as manufacturing, retail, real estate, healthcare and finance and accounting for 60–70 per cent of the country’s GDP.

“Such Family Offices have catalysed the creation of jobs, entrepreneurship and a culture of self-reliance in the country, unlike those that have gone south owing to a lack of adaptability, succession planning, innovation, and effective governance,” said the report.

Family Offices have also evolved into holistic service providers, championing ESG and technology for sustainable wealth.

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“Over recent years, Family Offices have secured an integral spot in India’s financial ecosystem, offering specialised services tailored to the unique needs of high-net-worth individuals and business families,” said Falguni Shah, Partner and Leader, Entrepreneurial and Private Business, PwC India.

Amid these evolving trends, Family Offices also face several challenges. Building trust within family members and the family office is crucial but complex due to varying mindsets and interests.

“Family Offices in India are transforming wealth management by embracing technology, global diversification, and ESG principles. Their evolution from wealth preservation to impactful investing is crucial for sustainable growth and positive societal impact,” said Jayant Kumaar, Partner, Deals and Family Office Leader, PwC India.

–IANS

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