Connect with us

Sci/tech

Leaky blood vessels behind Long Covid-linked brain fog, says study

Published

on

Dublin, Feb 22 (IANS) In a major discovery, a team of scientists discovered disruption to the blood vessels in the brains of patients suffering from Long Covid and ‘brain fog’.

The team from Trinity College Dublin showed that this blood vessel “leakiness” was able to objectively distinguish those patients with brain fog and cognitive decline compared to patients suffering from Long Covid but not with brain fog.

They also uncovered a novel form of MRI scan that shows how Long Covid can affect the human brain’s delicate network of blood vessels.

The findings were reported in the journal Nature Neuroscience.

“For the first time, we have been able to show that leaky blood vessels in the human brain, in tandem with a hyperactive immune system may be the key drivers of brain fog associated with Long Covid This is critically important, as understanding the underlying cause of these conditions will allow us to develop targeted therapies for patients in the future,” said Prof. Matthew Campbell, Professor in Genetics and Head of Genetics at Trinity.

ALSO READ:  CSC partners ONDC to enable e-commerce access to rural citizens across India

“The findings will now likely change the landscape of how we understand and treat post-viral neurological conditions. It also confirms that the neurological symptoms of Long Covid are measurable with real and demonstrable metabolic and vascular changes in the brain,” added Prof. Colin Doherty, Professor of Neurology and Head of the School of Medicine at Trinity.

In recent years, it has become apparent that many neurological conditions such as multiple sclerosis (MS) likely have a viral infection as the initiating event that triggers the pathology.

However, proving that direct link has always been challenging.

“The concept that many other viral infections that lead to post-viral syndromes might drive blood vessel leakage in the brain is potentially game changing and is under active investigation by the team,” Prof. Campbell said.

Long Covid has now become a major public health issue since the outbreak of the pandemic in 2020. While international incidence rates vary, it is estimated to affect up to 10 per cent of patients infected with the SARS-CoV2 virus.

ALSO READ:  Hyundai debuts Casper Electric SUV, showcases Genesis concepts

Of these patients suffering from Long Covid, just under 50 per cent of them report some form of lingering neurological effect such as cognitive decline, fatigue, and brain fog. Long Covid has up to 200 reported symptoms to date, but in general, patients report lingering symptoms such as fatigue, shortness of breath, problems with memory and thinking, and joint/muscle pain.

–IANS

rvt/vd

Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Sci/tech

NSE warns investors against persons promising assured returns in stock market

Published

on

By

New Delhi, July 3 (IANS) The National Stock Exchange (NSE) issued an advisory on Wednesday cautioning investors of certain individuals and Telegram channels offering securities market tips and assured returns on stock market investments.

The exchange said in a statement that investors are cautioned and advised not to subscribe to any such scheme/product offered by any person/entity offering indicative/assured/guaranteed returns in the stock market, as the same is prohibited by law.

The NSE said that a person named “Ajay Kumar Sharma” operating through the mobile number “7878337029” and Telegram channel “Bharat Trading Yatra” and an individual named “Ranveer Singh” operating through the mobile number “9076273946” and Telegram channel “Bullish Stocks” — are “providing assured returns on investment in stock market and offering to handle trading account of investor by asking investors to share their Login ID/password”.

“It may also be noted that the said person/entity are not registered either as a member or authorised person of any registered member of the NSE,” said the exchange.

ALSO READ:  CSC partners ONDC to enable e-commerce access to rural citizens across India

The stock exchange also advised investors not to share their trading credentials, such as user ID/password, with anyone.

In addition, the NSE mentioned that participation in such prohibited schemes is at investors’ own risk, cost and consequences as “such schemes are neither approved nor endorsed by the exchange”.

–IANS

shs/pgh

Continue Reading

Sci/tech

Low rainfall & high CO2 can replace India's biodiversity hotspots: Study

Published

on

By

New Delhi, July 3 (IANS) Even as greenhouse gasses are increasing unprecedentedly, it can decrease rainfall in the equatorial region as well as affect India’s biodiversity hotspots, according to a new study on Wednesday.

The study showed that it will potentially replace India’s biodiversity hotspots consisting of evergreen forests in the Western Ghats, northeast India, and the Andamans with deciduous forests.

For the study researchers from Birbal Sahni Institute of Palaeosciences (BSIP), an autonomous institute of the Department of Science and Technology, used fossil pollen and carbon isotope data from the Eocene Thermal Maximum 2 (ETM-2), also known as H-1 or Elmo.

It is a period of global warming that occurred around 54 million years ago.

In addition to global warming, during this period the Indian plate also lingered near the equator during its journey from the southern to northern hemisphere.

“This makes the Indian plate a perfect natural laboratory that offers a peculiar opportunity to understand the vegetation-climate relationship near the equator during the ETM-2,” the researchers said.

ALSO READ:  UPI payments see surge in India, leading people to overspending too: Experts

Based on the availability of fossils from ETM2, the team selected the Panandhro Lignite Mine of Kutch in Gujarat and collected fossil pollen from there.

Their findings, published in the journal Geoscience Frontiers, found that when atmospheric carbon dioxide (CO2) concentration was more than 1000 parts per million by volume (ppmv) near the palaeo-equator, the rainfall decreased significantly. It led to the expansion of deciduous forests.

The study also raises important questions about the survival of equatorial/ tropical rainforests and biodiversity hotspots under increased carbon emissions. It can also help understand the relationship between CO2 and hydrological cycle and aid in the future conservation of biodiversity hotspots.

–IANS

rvt/pgh

Continue Reading

Sci/tech

JNCASR team propose a new measure of flexibility for crystals

Published

on

By

New Delhi, July 3 (IANS) Researchers at the Jawaharlal Nehru Centre for Advanced Scientific Research, (JNCASR), an autonomous institution under the Department of Science & Technology, have introduced a novel quantitative measure of mechanical flexibility for crystals.

The measure can be used to screen materials databases to identify next-generation flexible materials, said the team.

They carried out an in-depth analysis of the mechanisms underlying the flexibility of crystals of Metal-organic frameworks (MOFs) — a large class of crystalline materials that possess the remarkable ability to absorb gasses, such as carbon dioxide, and store them as well as act as filters for crude oil purification.

The team attributed the flexibility to large structural rearrangements associated with soft and hard vibrations within a crystal that strongly couple to strain fields.

The analysis opens doors to innovative materials with diverse applications in various industries, said the researchers.

MOFs derive their ability from the presence of nanopores, enhancing their surface areas that, in turn, make them adept at absorbing and storing gases. However, limited stability and mechanical weakness have hindered their broader applications, which was addressed by the new measure.

ALSO READ:  CSC partners ONDC to enable e-commerce access to rural citizens across India

The new findings, published in the journal Physical Review B, present groundbreaking insights into the origin of mechanical flexibility. Flexibility in crystals has, historically, been assessed in terms of a parameter called elastic modulus — a measure of a material’s resistance to strain-induced deformation, but, on the contrary, the study “proposes a unique theoretical measure based on the fractional release of elastic stress or strain energy through internal structural rearrangements under symmetry constraints”.

Using theoretical calculations, the team examined the flexibility of four different systems with varying elastic stiffness and chemistries. The results showed that “flexibility arises from large structural rearrangements associated with soft and hard vibrations within a crystal that strongly couples to strain fields”.

The newfound measure of flexibility is also poised to revolutionise materials science, especially in the context of MOFs. “This theoretical framework enables the screening of thousands of materials in databases, providing a cost-effective and efficient way to identify potential candidates for experimental testing. The design of ultra-flexible crystals becomes more achievable, offering a practical solution to the challenges posed by traditional experimental methods,” said Professor Umesh V. Waghmare from the Theoretical Sciences Unit at JNCASR.

ALSO READ:  Meta’s Oversight Board extends its scope to Instagram Threads

The potential applications of this research extend beyond the realm of physics, opening doors to innovative materials with diverse applications in various industries, the team said.

–IANS

rvt/vd

Continue Reading

Sci/tech

247 mn Indian 'entrepreneurial households' to drive $95 trillion in transaction value by 2043

Published

on

By

New Delhi, July 3 (IANS) India now has 247 million “entrepreneurial households” responsible for a whopping $8.8 trillion in transaction value for the fiscal year 2023, and expected to grow to $95.2 trillion by 2043 with an annual growth rate of 12.7 per cent, a report showed on Wednesday.

These “entrepreneurial households” will be key players in India’s next economic wave.

According to the report by Enmasse, Praxis Global Alliance, and Elevar Equity, the “entrepreneurial households” generate multiple income streams and use them along with borrowed funds to engage in high-value transactions involving important goods and services and business investments.

The report introduced a new term, ‘Core Transaction Value (CTV)’, which measures the total economic activity of these households, including all their earnings, borrowings, and spending.

“Given that we were taking a fresh approach to market sizing that felt almost impossible to begin — putting the customer segment first and not focusing on a sector or a product – we felt it is useful to provide additional visibility into our analysis and estimates, with triangulations from multiple sources,” said Madhur Singhal, Managing Partner and CEO, Praxis Global Alliance.

ALSO READ:  Indian healthcare sector faced 6,935 cyberattacks per week in last 6 months: Report

“Brands targeting these households have seen high returns on investment, comparable to the top companies listed in the Nifty50 stock index,” the findings showed.

The report underscored the importance of these households in driving future economic growth and prosperity in India.

“For entrepreneurs and investors, this presents a unique opportunity to innovate and invest in this rapidly growing market, potentially reaping substantial returns,” it added.

The “entrepreneurial households” are characterised by their savvy allocation of cash towards consumption and investments, which is indicative of their economic vitality, more than traditional income measures.

–IANS

na/vd

Continue Reading

Sci/tech

India now has over 300 Family Offices from 45 in 2018 with smaller cities in focus: Report

Published

on

By

New Delhi, July 3 (IANS) Driven by robust economic growth in India, the country now has over 300 Family Offices as against 45 in 2018 who are catalysing the creation of jobs with an emphasis on responsible investing, a report showed on Wednesday.

Their number is set to rise exponentially, with promoters building impressive businesses in tier 2 and 3 cities, said the PwC India’s latest report.

The Indian economy is on a roll and contributing to its expansion are family businesses, both large conglomerates and small-to-medium-sized enterprises, spanning sectors such as manufacturing, retail, real estate, healthcare and finance and accounting for 60–70 per cent of the country’s GDP.

“Such Family Offices have catalysed the creation of jobs, entrepreneurship and a culture of self-reliance in the country, unlike those that have gone south owing to a lack of adaptability, succession planning, innovation, and effective governance,” said the report.

Family Offices have also evolved into holistic service providers, championing ESG and technology for sustainable wealth.

ALSO READ:  Musk’s X cracks down on deepfakes with improved image matching

“Over recent years, Family Offices have secured an integral spot in India’s financial ecosystem, offering specialised services tailored to the unique needs of high-net-worth individuals and business families,” said Falguni Shah, Partner and Leader, Entrepreneurial and Private Business, PwC India.

Amid these evolving trends, Family Offices also face several challenges. Building trust within family members and the family office is crucial but complex due to varying mindsets and interests.

“Family Offices in India are transforming wealth management by embracing technology, global diversification, and ESG principles. Their evolution from wealth preservation to impactful investing is crucial for sustainable growth and positive societal impact,” said Jayant Kumaar, Partner, Deals and Family Office Leader, PwC India.

–IANS

na/svn

Continue Reading

Trending