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Here's how chronic stress boosts cancer spread

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New York, Feb 24 (IANS) In a breakthrough study, a team of researchers have shown how chronic stress can aid in cancer spread.

Chronic stress can increase our risk for heart disease and strokes. While it is also known to help cancer spread, how this works has remained a mystery.

The team from Cold Spring Harbor Laboratory (CSHL) in the US discovered that stress causes certain white blood cells called neutrophils to form sticky web-like structures that make body tissues more susceptible to metastasis.

The finding, published in the journal Cancer Cell, could point to new treatment strategies that stop cancer’s spread before it starts.

“Stress is something we cannot really avoid in cancer patients. You can imagine if you are diagnosed, you cannot stop thinking about the disease or insurance or family. So it is very important to understand how stress works on us,” said Xue-Yan He, a former postdoc in Cold Spring Harbor Laboratory (CSHL).

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The team arrived at their discovery by mimicking chronic stress in mice with cancer. They first removed tumours that had been growing in mice’s breasts and spreading cancer cells to their lungs. Next, they exposed the mice to stress.

“Saw this scary increase in metastatic lesions in these animals. It was up to a fourfold increase in metastasis,” said Mikala Egeblad, Adjunct Professor at CSHL.

The team found that stress hormones called glucocorticoids acted on the neutrophils. These “stressed” neutrophils formed spider-web-like structures called NETs (neutrophil extracellular traps). NETs form when neutrophils expel DNA. Normally, they can defend us against invading microorganisms. However, in cancer, NETs create a metastasis-friendly environment.

To confirm that stress triggers NET formation, leading to increased metastasis, she performed three tests.

First, she removed neutrophils from the mice using antibodies. Next, she injected a NET-destroying drug into the animals. Lastly, she used mice whose neutrophils couldn’t respond to glucocorticoids. Each test achieved similar results.

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“The stressed mice no longer developed more metastasis,” she said.

Notably, the team found that chronic stress caused NET formation to modify lung tissue even in mice without cancer.

“It’s almost preparing your tissue for getting cancer,” Egeblad explained.

“Reducing stress should be a component of cancer treatment and prevention,” said CSHL Professor Linda Van Aelst.

The team also speculates that future drugs preventing NET formation could benefit patients whose cancer hasn’t yet metastasised. Such new treatments could slow or stop cancer’s spread, offering much-needed relief.

–IANS

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PM Modi hails Sudha Murty's maiden Rajya Sabha speech on women’s health

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New Delhi, July 3 (IANS) Prime Minister Narendra Modi on Wednesday commended author and philanthropist Sudha Murty — newly elected to the Rajya Sabha — for her impactful maiden speech during the discussion on motion of thanks to the President’s Address in the Upper House of the Parliament.

Speaking about women’s health, she cited her father’s poignant remark – when a mother dies it is counted as one death in the hospital, but for the family, a mother is lost forever.

PM Modi expressed gratitude to Sudha Murty for her comprehensive discussion on women’s health, acknowledging her as she stood up and greeted him.

“I want to thank Sudha Murty for speaking in detail about women’s health,” PM Modi said.

While discussing Sudha Murty’s emotional remarks about mothers, the Prime Minister emphasised that over the past decade, his government has prioritised women’s health and sanitation as a crucial sector.

“Our country’s women have benefited from the toilets we have made,” PM Modi said while replying to a debate on a motion thanking President Droupadi Murmu for her address to the joint sitting of Parliament last week.

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PM Modi also highlighted that his government has distributed sanitary pads and launched a vaccination program for pregnant women.

Sudha Murty advocated for a government-backed vaccination programme aimed at combatting cervical cancer.

“There is a vaccination which is given to girls, between the age of nine and 14, known as a cervical vaccination. If the girls take that, it (cancer) can be avoided… we should promote vaccination for the benefit of our girls because prevention is better than cure,” she said in her first speech in Rajya Sabha.

She suggested that since the government successfully managed a significant vaccination drive during Covid-19, providing cervical vaccination to girls aged 9-14 years should not be very challenging.

Sudha Murty, nominated to the Upper House of the Parliament by President Droupadi Murmu on the eve of International Women’s Day, noted that the cervical vaccination, developed in the West, has been in use for the past 20 years.

“It worked very well. It is not expensive. Today, it is Rs 1,400 for people like me who are in the field. If the government intervenes and negotiates… you can bring it to Rs 700-800. We have such a large population. It will be beneficial for our girls in the future,” she said during her 13-minute address.

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–IANS

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India backs global standards for spices, vegetable oils at international food trade meet

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New Delhi, July 3 (IANS) India has backed global standards for spices and vegetable oils at the 86th session of the Executive Committee (CCEXEC) of the Codex Alimentarius Commission (CAC), the Ministry of Health and Family Welfare (MoHFW) said on Wednesday.

The CCEXEC, ongoing at Food and Agriculture Organization (FAO) headquarters in Rome from July 1-5, plays a critical role in reviewing proposals for new work and monitoring the progress of standards development.

The CAC, an international body established by the FAO and the World Health Organisation (WHO), aims to protect consumer health and promote fair practices in food trade.

During the session, India, represented by G. Kamala Vardhana Rao, CEO of the Food Safety and Standards Authority of India (FSSAI), strongly supported the advancement of standards development for various spices, including small cardamom, turmeric, and vanilla, the ministry said.

“This initiative is particularly significant for India, being a major producer and exporter of these spices, as it would facilitate smoother international trade,” it added.

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India also “backed the progression of standards for named vegetable oils, guidelines for the control of Shiga toxin-producing Escherichia coli”.

It also called for the safe use and reuse of water in food production and processing and championed the proposal for developing Codex guidance on food safety considerations related to the use of recycled materials in food packaging.

It is “crucial in addressing global challenges such as climate change, environmental protection, and sustainability,” the ministry said.

Further, at the session, India shared its experience with the FSSAI guidelines on recycling post-consumer PET for food contact applications. “India’s participation, as a member, in the High-level Executive Committee (CCEXEC) underscores its dedication to establishing robust food safety standards and promoting fair practices in the global food trade, reflecting its pivotal role in the international food industry,” the ministry noted.

–IANS

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New AI model to boost patient response to cancer therapy

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New Delhi, July 3 (IANS) Australian researchers have developed a new artificial intelligence (AI) tool that can help to select the most suitable treatment for cancer patients.

The new tool DeepPT, developed by researchers at The Australian National University (ANU), predicts a patient’s messenger RNA (mRNA) profile.

This mRNA — essential for protein production — is also the key molecular information for personalised cancer medicine.

When combined with another tool called ENLIGHT, DeepPT was found to successfully predict a patient’s response to cancer therapies across multiple types of cancer, said lead author Dr Danh-Tai Hoang from ANU.

Dr Hoang said, “DeepPT was trained on over 5,500 patients across 16 prevalent cancer types, including breast, lung, head and neck, cervical and pancreatic cancers”.

The tool, detailed in the journal Nature Cancer, showed an improvement in patient response rate. The AI tool draws on microscopic pictures of patient tissue called histopathology images, also providing another key benefit for patients.

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“This cuts down on delays in processing complex molecular data, which can take weeks,” Dr Hoang said, as any delay can affect patients with high-grade tumours who might require immediate treatment.

“In contrast, histopathology images are routinely available, cost-effective, and timely,” Hoang added.

–IANS

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Limit ghee, coconut oil if you have fatty liver disease: Expert

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New Delhi, July 3 (IANS) As fatty liver disease is increasing in India, a noted hepatologist on Wednesday advised limiting consumption of saturated fats like ghee and coconut oil.

Fatty liver disease is related to obesity and diabetes. Consuming excessive carbohydrates can raise insulin levels, and chronic high insulin levels lead to insulin resistance. This disrupts metabolism and converts excess glucose into fatty acids, which are stored in the liver.

It can be classified into two main types: alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD/MASLD) — linked to liver inflammation and damage, eventually leading to fibrosis, cirrhosis, or liver cancer.

“In the Indian context, if you have metabolic-disorder-associated fatty liver disease (previously NAFLD), remember to limit saturated fat sources in your diet,” said Dr Abby Phillips, popularly known as LiverDoc, on the social media platform X.com.

“This means limiting foods containing Ghee, clarified butter (north India), Coconut oil (south India), and Palm oil (processed/ ultra-processed foods),” he explained, adding that “saturated fats increase liver triglycerides and hence liver fat and inflammation.”

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While ghee is traditionally considered healthy, the doctor noted that it “is not a superfood. It is a super danger. It is almost all fat, and more than 60 per cent is saturated (unhealthy) fat.”

He stressed the need to replace it with “healthier (vegetable) seed oils that have low saturated fat and trans-fat content.”

Dr Abby also recommended using a diverse range of seed oils in daily cooking. Instead of frying food items, he suggested “bake, boil, broil, grill, or steaming foods.”

He also called out to “increase portions of plant-based protein in daily meals and to add daily fresh cut fruit portions (instead of fruit juicing).”

“This is far more important than limiting meat (including lean meat more than red meat), fish, and eggs — all of which can be consumed in their recommended daily/weekly intake,” the doctor said.

–IANS

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Aspirin can prevent complications in pregnancy caused by flu infections: Study

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New Delhi, July 3 (IANS) Taking low-dose aspirin may treat flu-induced blood vessel inflammation, creating better blood flow to the placenta during pregnancy, according to the world-first study conducted in mice.

Low-dose aspirin is commonly taken to prevent preeclampsia — high blood pressure condition in pregnancy — as it stops the body from creating chemicals that cause inflammation.

The study, led by an international team from RMIT University in Australia in collaboration with a team from Trinity College Dublin, Ireland, examined whether the treatment for preeclampsia could be applied to flu infections.

They found very promising results in animal studies — mice treated daily with low-dose aspirin had less inflammation and improved foetal development and offspring survival.

On the contrary, foetuses and placenta from mice with influenza A were smaller than those from uninfected mice. They also found the foetuses with low blood oxygen and poor blood vessel development.

Flu infections during pregnancy can resemble preeclampsia, a pregnancy complication that causes inflammation to the aorta and blood vessels, said lead researcher Dr Stella Liong, a post-doctoral research student at RMIT University in Melbourne.

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She explained: “When the vascular system gets inflamed, it leads to poor blood flow and affects the aorta’s function.”

“This is especially a problem during pregnancy where good blood flow to the placenta is crucial to the development of the foetus.”

While the research still awaits human clinical trials, Liong said low-dose aspirin is already recognised as safe to take during pregnancy.

However, pregnant people must seek medical advice before taking new medications, the research team said.

–IANS

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