Sci/tech
A simple blood test to predict risk of heart attack within six months
London, Feb 13 (IANS) A simple blood test can help detect several important biological processes that are active during the months before a heart attack, suggests a study.
Heart attacks are the most common cause of death in the world and are increasing globally. Many high-risk people are not identified or do not take their preventive treatment.
Now, researchers at Uppsala University in Sweden have found that the blood test can predict if you are at an increased risk of having a heart attack within six months.
The problem, according to the researchers, is that risk factors have previously been verified in studies involving five to ten years of follow-up, where only factors that are stable over time can be identified.
“However, we know that the time just before a heart attack is very dynamic. For example, the risk of a heart attack doubles during the month a divorce, and the risk of a fatal heart event is five times as high during the week after a cancer diagnosis,” said Johan Sundstrom, a cardiologist and professor of epidemiology at Uppsala University.
“We wanted to develop methods that would enable the health services to identify people who will soon suffer their first heart attack,” Sundstrom said, in the paper published in the journal Nature Cardiovascular Research.
The research group had access to blood samples from 169,053 individuals without prior cardiovascular disease in six European cohorts. Within six months, 420 of these people suffered their first heart attack. Their blood was then compared with blood from 1,598 healthy members of the cohorts.
“We identified around 90 molecules that were linked to a risk of a first heart attack. However, the samples that are already taken in health care now are enough to predict the risk. We hope that this will increase people’s motivation to take their preventive medicine or stop smoking, for example,” Sundstrom said.
The researchers have also developed a simple online tool in which anyone can find out their risk of having a heart attack within six months.
“This was one of the aims of the entire study since we know that people feel relatively low motivation to follow preventive treatments. If you find out that you happen to have an increased risk of suffering a heart attack soon, perhaps you will feel more motivated to prevent it,” Sundstrom said.
The researchers will now study the 90 or so new molecules to understand them better and see whether there are any possibilities for treatment.
–IANS
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Sci/tech
Indian startups raised nearly $176 million across 16 deals in July 1st week
New Delhi, July 6 (IANS) The Indian startup ecosystem raised nearly $176 million in funding across 16 deals in the first week of this month.
In the biggest funding round, fashion e-commerce platform Purplle secured $120 million led by Abu Dhabi Investment Authority.
Agri-tech startup Arya.ag also announced to raise $29 million led by impact investment firm Blue Earth Capital.
Video telematics startup Cautio also announced a pre-seed raise of Rs 6.5 crore led by Antler, 8i Ventures and AU Small Finance Bank.
Homegrown startups have raised nearly $7 billion in funding during the first half (H1) of 2024, more than the $5.92 billion raised in H1 2023.
Also, the fintech ecosystem achieved a significant milestone in the first half of this year by ranking among the top three funded globally, alongside the US and the UK.
–IANS
na/uk
Sci/tech
Facing unexplainable mood disorders? You may be low on Vitamin B 12: Doctors
New Delhi, July 6 (IANS) Vitamin B-12 plays a key role in producing brain chemicals that affect mood and other brain functions, said doctors on Saturday.
Vitamin B-12 (also known as cobalamin) plays a crucial role in the formation of red blood cells, cell metabolism, nerve function, and the production of DNA.
Some common symptoms of Vitamin B12 deficiency include strange sensations, numbness, or tingling in the hands, legs, or feet, difficulty walking (staggering, balance problems), anaemia, difficulty thinking and reasoning (cognitive difficulties), memory loss, weakness, or fatigue.
“Vitamin B-12 and other B vitamins play a crucial role in producing brain chemicals that affect mood and other brain functions. Low levels of B-12, as well as other B vitamins like vitamin B-6 and folate, may be linked to depression,” Dr Anshu Rohtagi, Senior Consultant, Department of Neurology, Sir Ganga Ram Hospital, told IANS.
“The deficiencies can result from poor diet or difficulties in absorbing the vitamins consumed. So, maintaining adequate B-12 level is essential for overall well-being, including mood regulation,” she added.
Vitamin B-12 is majorly found in poultry, meat, fish, and dairy products. It is available as an oral supplement, as injections, or nasal spray.
People who consume a vegetarian or vegan diet may be more prone to deficiency as plant foods do not contain vitamin B-12. The elderly and people with digestive tract conditions that affect the absorption of nutrients also are susceptible to vitamin B-12 deficiency.
“Vitamin B12 plays a crucial role in producing brain chemicals like serotonin, which helps regulate mood. When B12 levels dip, these chemicals can become imbalanced, potentially leading to symptoms like mood swings, irritability, and even depression,” Dr Guruprasad Hosurkar, Additional Director – Neurology, Fortis Hospital, Bannerghatta Road, Bengaluru, told IANS.
Importantly, the doctor explained that the “connection is not gender-specific. Both men and women can experience mood changes due to B12 deficiency”.
While research is ongoing, studies suggest a link between low B12 and depression, with some showing improvement in mood with B12 supplementation.
However, it’s important to note that mood swings can have many causes, and a doctor should be consulted to rule out other factors and determine if a B12 deficiency is present, Dr Guruprasad said.
“Vitamin B12 deficiency causes several neurological symptoms such as tingling, numbness & burning of feet, imbalance, memory impairment, mood disorders, psychosis, seizures, and Parkinsonism,” explained Dr Sudhir Kumar, from Indraprastha Apollo Hospitals, Hyderabad in a post on social media platform X.
“In a patient presenting with neurological or psychiatric symptoms, suspect vitamin B12 deficiency as a cause (especially if there is no obvious cause identified). Early diagnosis and prompt initiation of treatment rapidly improves patient’s symptoms,” he added.
The doctors also stressed the need to maintain a healthy lifestyle and advised key behaviours such as managing high blood pressure, and blood sugar, quitting smoking, and alcohol, staying physically active, getting adequate sleep, and managing stress.
–IANS
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Sci/tech
Former NASA astronaut Steve Lee Smith to headline Kerala AI conclave
Kochi, July 6 (IANS) Former NASA astronaut and technology executive Steve Lee Smith will be the highlight of the two-day first International GenAI Conclave to be hosted by the Kerala Government in Kochi on July 11 and 12.
This event is in association with IBM. Chief Minister Pinarayi Vijayan will inaugurate it.
A veteran astronaut, Smith flew into space four times at 28,000 KMH on the space shuttle during his stint in NASA, covering 16 million miles.
He also performed seven spacewalks, including repairs of the Hubble Space Telescope.
Smith will speak on ‘Lessons Learned from A Skywalker’ at the conclave.
The event will be attended by leading lights in this area to explore the transformative potential of AI and its impact on society and the economy.
The GenAI conclave aims to transform Kerala as an AI destination and showcase the state’s perspectives on industry 4.0, besides giving a thrust to the growth of the economy.
Besides developers, universities, students, media and analysts, the conclave will feature demos, activations, interactions with industry experts, panel discussions and lectures.
Participants will also get a first-hand experience in the latest advancements in the AI sector.
–IANS
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Sci/tech
Mice with functional humanised immune system shows promise
New Delhi, July 6 (IANS) A first-of-its-kind mice model with a fully functional human immune system and a human-like gut microbiome has shown promise of mounting specific antibody responses.
To date, researchers have not developed a fully functional human immune system, but only those with a brief lifespan that do not mount efficient immune responses, making them unsuitable for the development of in vivo human immunotherapies, human disease modelling, or human vaccine development.
Developed by scientists at The University of Texas in the US, the new model will overcome limitations of currently available in vivo human models and is a breakthrough for biomedical research and promises new insight into immunotherapy development and disease modelling.
Detailed in the journal Nature Immunology, the new humanised mice, called TruHuX (for truly human, or THX), possess a fully developed and fully functional human immune system, including lymph nodes, germinal centres, thymus human epithelial cells, human T and B lymphocytes, memory B lymphocytes, and plasma cells making highly specific antibody and autoantibodies identical to those of humans.
THX mice mount mature neutralising antibody responses to Salmonella Typhimurium and SARS-CoV-2 virus Spike S1 RBD after vaccination with Salmonella flagellin and the Pfizer Covid-19 mRNA vaccine, respectively.
It is also amenable to developing full-fledged systemic lupus autoimmunity after an injection of pristane — an oil that triggers an inflammatory response.
“THX mice provide a platform for human immune system studies, development of human vaccines, and testing of therapeutics,” said Paolo Casali, Professor at the University of Texas School of Medicine in San Antonio, US.
They do this “by critically leveraging oestrogen activity to support human stem cell and human immune cell differentiation and antibody responses”, he added.
–IANS
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Sci/tech
Atal Innovation Mission empowering innovators in Tier 2 & 3 cities: Director
New Delhi, July 6 (IANS) Atal Innovation Mission’s (AIM) Community Innovator Fellows (CIFs) programme is empowering innovators in Tier 2 and Tier 3 cities, said Dr. Chintan Vaishnav, Mission Director at AIM.
He said this while delivering a keynote address at NITI Aayog marking the celebration of the graduation of its second batch of CIFs on Friday.
Dr. Chintan underscored the programme’s pivotal role in advancing solutions across healthcare, education, agriculture, and financial services, resonating deeply with the ethos of sustainable development.
“We have now established robust institutions that seamlessly integrate business incubation with academia. This well-designed project aspires to be a model of excellence,” Dr. Vaishnav said.
He noted that the Community Innovator initiative “captures the aspirations of youth eager to go beyond traditional boundaries in innovation and startups. It embodies both rigour and relevance, truly inspiring in its mission and impact.”
AIM, through its Atal Community Innovation Centres (ACIC) programme has envisaged serving the unserved/underserved areas of the country, providing support to every grassroots innovator, and working towards accelerating the pathway to reach SDGs 2030.
“These innovators serve as role models not only for their communities but also for society at large. I’m delighted to witness each business prospering — it’s like shaping raw gold into a precious jewel,” said Anurag Pratap Singh, Vice President & CSR Leader at Capgemini India.
Dr. Suresh Reddy, Lead CSR & Director at SRF Foundation, reflected on the impact of social entrepreneurship in addressing community challenges.
–IANS
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